SuperGuy wrote:442 can beat any opponent if the team in question plays well enough.
Man United lost the last two Champions league finals in the midfield.
Playing a lone striker just limits your chance of getting goals.
3-4-3 FTW. With left and right midfielder moving to defence when necessary AND supporting counters, the 3 strikers will be able to receive and keep the ball. It prevents isolation and team reliance on long balls. All in all, I'd advocate such a setup.
And of course 'if the team in question plays well enough', even a 1-1-8 (or, somewhat more fun, 1-8-1) could get you a victory.